• Cellular mechanisms of estrogens and endocrine disrupting agents in mediated the development and progression of cancers
• Cancer therapies targeting cell cycle machinery and apoptotic signaling pathway
• Signal transduction cross-talk between cholinergic and estrogenic pathway and its involvement in environmental-related diseases

Publications:

1. atcharasit, P., Thiantanawat, A., Satayavivad, J. GSK3 promotes arsenite-induced apoptosis via facilitation of mitochondria disruption. J. Appl. Toxicol., 2007 (In Press).
2. Chantara, W., Watcharasit, P., Thiantanawat, A., Satayavivad, J. Acrylonitrile-induced Extracellular signal-regulated kinase (ERK) activation via protein kinase C (PKC) in SK-N-SH neuroblastoma cells. J. Appl. Toxicol., 26(6): 517-523, 2006.
3. Long, B. J., Jelovac, D., Handratta, V., Thiantanawat, A., MacPherson, N., Ragaz, J., Goloubeva, O. G., and Brodie, A. M. Therapeutic strategies using the aromatase inhibitor letrozole and tamoxifen in a breast cancer model. J. Natl. Cancer Inst., 96(6): 456-465, 2004.
4. Thiantanawat, A., Long, B. J., and Brodie, A. M. Signaling pathways of apoptosis activated by aromatase inhibitors and antiestrogens. Cancer Res., 63(22): 8037-8050, 2003.
5. Long, B. J., Jelovac, D., Thiantanawat, A., and Brodie, A. M. The effect of second-line antiestrogen therapy on breast tumor growth after first-line treatment with the aromatase inhibitor letrozole: Long-term studies using the intratumoral aromatase postmenopausal breast cancer model. Clin. Cancer Res., 8: 2378-2388, 2002.
6. Long, B. J., Tilghman, S. L., Yue, W., Thiantanawat, A., Grigoryev, D. N., and Brodie, A. M. H. The steroidal antiestrogen ICI 182,780 is an inhibitor of cellular aromatase activity. J. Steroid Biochem. Molec. Biol., 67: 293-304, 1998.
7. Satayavivad, J., Thiantanawat, A., Tuntawiroon, J., Watcharasit, P., and Ruchirawat, M. Alterations of central muscarinic functions during subchronic exposure to acrylonitrile in rats. Res. Com. Biol. Psycho. Psychi., 23: 29-41: 1998.
8. Satayavivad J, Sirapat W, Thiantanawat A. Neurological effects of chronic exposure to low doses of paraquat in rats. Res. Comm. in Pharmacol and Toxicol., 2: 269-282, 1997.
9. Satayavivad J, Bunyapraphatsara N, Thiantanawat A, Kositchaiwat U. Hypoglycemic activity of the aqueous extract of Schefflera leucantha Viguier in rats. Thai Journal Phytopharmacy, 3: 1-5, 1996.