|
|
Dr. Rojana Sukchawalit
Email:
rojana@cri.or.th
Office: Biomedical Science Building, 8th
floor, Zone A
Phone: (66)2 5740622-33 ext. 3802 |
Research Interests:
Due to both the necessity of iron for physiological functions and also the toxicity of excess iron resulting from the formation of iron-catalyzed reactive oxygen species, therefore, iron homeostasis is tightly regulated in bacteria to ensure survival. The current research aims at a better understanding of the mechanisms by which phytopathogenic bacteria satisfy their iron demands and prevent iron-induced toxicity. Characterization of iron-sensing regulators, Fur (ferric uptake regulator), RirA (rhizobial iron regulator) and Irr (iron response regulator) from Agrobacterium
tumefaciens would help to understand iron regulation and homeostasis in this phytopathogen, as well as the impact of the regulators on bacterial survival during plant-pathogen interactions. Identification of iron-responsive regulators required for bacterial survival and virulence not only gain insight into species-specific differences in complex iron regulation but also provide potential targets for novel effective antimicrobial agent used for controlling diseases in economic crops.
Publications:
- Kitphati W., Ngok-Ngam P., Suwanmaneerat S.,
Sukchawalit R., and S. Mongkolsuk. 2007. Agrobacterium tumefaciens fur
has important physiological roles in iron and manganese homeostasis, the oxidative stress response, and full virulence. Appl. Environ. Microbiol. 73:4760-4768.
- Sukchawalit R., Prapagdee B., Charoenlap N., Vattanaviboon P., Mongkolsuk S. Protection of Xanthomonas against arsenic toxicity involves the peroxide-sensing transcription regulator OxyR. Res Microbiol 2005;156:30-4.
- Mongkolsuk S., Panmanee W., Atichartpongkul S., Vattanaviboon P., Whangsuk W., Fuangthong M., Eiamphungporn W., Sukchawalit R., Utamapongchai S. The repressor for an organic peroxide-inducible operon is uniquely regulated at multiple levels.
Mol Microbiol 2002;44:793-802.
|