CGCB 502 Spectroscopic Methods for Organic Compounds and Biomolecules (3 credits)
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Course Description :
The combination of various spectroscopic techniques is
essential in the structural elucidation of organic compounds, as well as in the kinetics
and dynamics of some large biomolecules, such as proteins and nucleotides. Various
techniques currently available and employed in modern spectroscopy will be discussed
with the emphasis on nuclear magnetic resonance (NMR) spectroscopy and mass
spectrometry (MS). The material includes topics in theoretical as well as practical
aspects of modern NMR and MS techniques for structure elucidation of small organic
compounds and for investigating various important properties of biomolecules. The
principles of infrared (IR) spectroscopy and ultraviolet (UV) spectroscopy will also
be highlighted. Additionally, the role of X-ray in the structure elucidation will be
covered. The course is problem-solving oriented, and a number of problems related to
structure elucidation ranging from simple to complex natural and synthetic compounds
and kinetics/dynamics of biomolecules will be covered based on all spectral techniques.
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