Dr. Prasat Kittakoop Email:  prasat@cri.or.th Office: Laboratory of Natural Products (R503 & R304B) Phone: (66)2 5740622-33 ext. 1519, 1514-5

     Dr. Prasat Kittakoop has focused on the isolation and characterization of bioactive natural products from plants, fungi, and marine invertebrates. Currently, he is interested in the application of nanoparticles in biological systems. In addition, asymmetric synthesis via Aldol or nitro condensation by enzymatic catalysis or by homogeneous catalysts is also of his interest.

Publications:

1. Vongvanich N, Kittakoop P, Charoenchai P, Intamas S, Danwisetkanjana K, Thebtaranonth Y. Combretastatins D-3 and D-4, New Macrocyclic Lactones from Getonia floribunda. Planta Med. 2005; 71: 191-193.
2. Na-Ranong S, Laoteng K, Kittakoop P, Tantichareon M, Cheevadhanarak S. Substrate Specificity and Preference of Δ6-Desaturase of Mucor rouxii. FEBS Lett. 2005; 579: 2744-2748.
3. Unagul P, Wongsa P, Kittakoop P, Intamas S, Srikitikulchai P, Tanticharoen M. Production of Red Pigments by the Insect Pathogenic Fungus Cordyceps unilateralis BCC 1869. J. Ind. Microbiol. Biotechnol. 2005; 32: 135-140.
4. Chomcheon P, Wiyakrutta S, Sriubolmas N, Ngamrojanavanich N, Isarangkul D, Kittakoop P. 3-Nitropropionic Acid (3-NPA), a Potent Antimycobacterial Agent from Endophytic Fungi: Is 3-NPA in Some Plants Produced by Endophytes? J. Nat. Prod. 2005; 68: 1103-1105.
5. Isaka M, Kittakoop P, Kirtikara K, Hywel-Jones NL, Thebtaranonth Y. Bioactive Substances from Insect Pathogenic Fungi. Acc. Chem. Res. 2005; 38: 813-823.
6. Prajoubklang A, Sirithunyalug B, Charoenchai P, Suvannakad R, Sriubolmas N, Piyamongkol S, Kongsaeree P, Kittakoop P. Bioactive Deoxypreussomerins and Dimeric Naphthoquinones from Diospyros ehretioides Fruits: Deoxypreussomerins May Not Be Plant Metabolites But May Be from Fungal Epiphytes or Endophytes. Chem. Biodivers. 2005; 2: 1358-1367.
7. Songarsa S, Rajviroongit S, Sae-Tang D, Hannongbua S, Kirtikara K, Kittakoop P. New Racemosol Derivatives as Potent Cyclooxygenase (COX) Inhibitors. Chem. Biodivers. 2005; 2: 1635-1647.
8. Sae-Lao P, Kittakoop P, Rajviroongit S. Total Synthesis of Racemosol and De-O-methylracemosol, Potent Cyclooxygenase (COX) Inhibitors and Antimalarial Agents. Tetrahedron Lett. 2006; 47: 345-348.
9. Na-Ranong S, Laoteng K, Kittakoop P, Tanticharoen M, Cheevadhanarak S. Targeted Mutagenesis of a Fatty Acid Δ6-Desaturase from Mucor Rouxii: Role of Amino Acid Residues Adjacent to Histidine-rich Motif II. Biochem. Biophys. Res. Commun. 2006; 339: 1029-1034.
10. Arthan D, Kittakoop P, Esen A, Svasti J. Furostanol Glycoside 26-ο-β-Glucosidase from the Leaves of Solanum torvum. Phytochemistry 2006; 67: 27-33.
11. Jongrungruangchok S, Tanasupawat S, Kittakoop P, Bavovada R, Kobayashi H, Kudo T. Identification of Streptomyces and Kitasatospora Strains from Thai Soils with Geldanamycin Production Strain. Actinomycetologica 2006; 20: 10-14.
12. Madla S, Kittakoop P, Wongsa P. Optimization of Culture Conditions for Production of Antimalarial Menisporopsin A by the Seed Fungus Menisporopsis theobromae BCC 4162. Lett. Appl. Microbiol. 2006; 43: 548-553.
13. Chomcheon P, Sriubolmas N, Wiyakrutta S, Ngamrojanavanich N, Chaichit N, Mahidol C, Ruchirawat S, Kittakoop P. Cyclopentenones, Scaffolds for Organic Synthesis Produced by the Endophytic Fungus, Mitosporic Dothideomycete sp. LRUB20. J. Nat. Prod. 2006; 69: 1351-1353.
14. Chinworrungsee M, Kittakoop P, Saenboonrueng J, Kongsaeree P, Thebtaranonth Y. Bioactive Compounds from the Seed Fungus Menisporopsis theobromae BCC 3975. J. Nat. Prod. 2006; 69: 1404-1410.
15. Vongvanich N, Kittakoop P, Charoenchai P, Intamas S, Sriklung K, Thebtaranonth Y. Antiplasmodial, Antimycobacterial, and Cytotoxic Principles from Camchaya calcarea. Planta Med. 2006; 72: 1427-1430.
16. Boonphong S, Puangsombat P, Baramee A, Mahidol C, Ruchirawat S, Kittakoop P. Bioactive Compounds from Bauhinia purpurea Possessing Antimalarial, Antimycobacterial, Antifungal, Anti-inflammatory, and Cytotoxic Activities. J. Nat. Prod. 2007; 70: 795-801.
17. Prachya S, Wiyakrutta S, Sriubolmas N, Ngamrojanavanich N, Mahidol C, Ruchirawat S, Kittakoop P. Cytotoxic Mycoepoxydiene Derivatives from an Endophytic Fungus Phomopsis sp. Isolated from Hydnocarpus anthelminthicus. Planta Med. 2007; in press.
18. Youngsa-ad W, Ngamrojanavanich N, Mahidol C, Ruchirawat S, Prawat H, Kittakoop P. Diterpenoids from the Roots of Croton oblongifolius. Planta Med. 2007; in press.