Dr. Somsak Ruchirawat Email:  somsak@cri.or.th Office: Laboratory of Medicinal Chemistry Phone: (66)2 5740622-33 ext. 1503

     Organic chemistry, medicinal chemistry, organic synthesis, natural products chemistry.

Publications:

1. Kanchanapoom T, Noiarsa P, Otsuka H, Ruchirawat S. Lignan, Phenolic and Iridoid Glycosides from Stereospermum cylindricum. Phytochemistry 2006; 67: 516-520.
2. Thasana N, Pisutjaroenpong S, Ruchirawat S. Two Protocols for the Conversion of Biphenol to Binaphthol: Synthesis of Diospyrol. Synlett 2006; 7: 1080-1084.
3. Athikomkulchai S, Prawat H, Thasana N, Ruangrungsi N, Ruchirawat S. COX-1, COX-2 Inhibitors and Antifungal Agents from Croton hutchinsonianus. Chem. Pharm. Bull. 2006; 54: 262-264.
4. Markmee S, Ruchirawat S, Prachyawarakorn V, Ingkaninan K, Khorana N. Isoquinoline Derivatives as Potential Acetylcholinesterase Inhibitors. Bioorg. Med. Chem. Lett. 2006; 16: 2170-2172.
5. Petchmanee T, Ploypradith P, Ruchirawat S. Solid-supported Acids for Debenzylation of Aryl Benzyl Ethers. J. Org. Chem. 2006; 71: 2892-2895.
6. Prachyawarakorn V, Mahidol C, Ruchirawat S. Pyranocoumarins from the Twigs of Mammea siamensis. Phytochemistry 2006; 67: 924-928.
7. Prachyawarakorn V, Mahidol C, Ruchirawat S. Siamenols A-D, Four New Coumarins from Mammea siamensis. Chem. Pharm. Bull. 2006; 54: 884-886.
8. Chomcheon P, Sriubolmas N, Wiyakrutta S, Ngamrojanavanich N, Chaichit N, Mahidol C, Ruchirawat S, Kittakoop P. Cyclopentenones, Scaffolds for Organic Synthesis Produced by the Endophytic Fungus, Mitosporic Dothideomycete sp. LRUB20. J. Nat. Prod. 2006; 69: 1351-1353.
9. Siripong P, Yahuafai J, Shimizu K, Ichikawa K, Yonezawa S, Asai T, Kanokmedakul K, Ruchirawat S, Oku N. Induction of Apoptosis in Tumor Cells by Three Naphthoquinone Esters Isolated from Thai Medicinal Plant: Rhinacanthus nasutus KURZ. Biol. Pharm. Bull. 2006; 29: 2070-6.
10. Siripong P, Yahuafai J, Shimizu K, Ichikawa K, Yonezawa S, Asai T, Kanokmedakul K, Ruchirawat S, Oku N. Antitumor Activity of Liposomal Naphthoquinone Esters Isolated from Thai Medicinal Plant: Rhinacanthus nasutus KURZ. Biol. Pharm. Bull. 2006; 29: 2279-2283.
11. Thisoda P, Rangkadilok N, Pholphana N, Worasuttayangkurn L, Ruchirawat S, Satayavivad J. Inhibitory Effect of Andrographis paniculata Extract and Its Active Diterpenoids on Platelet Aggregation. Eur. J. Pharmacol. 2006; 553: 39-45.
12. Worayuthakarn R, Thasana N, Ruchirawat S. Three Distinct Reactions of 3,4-Dihydroisoquinolines with Azlactones: Novel Synthesis of Imidazoloisoquinolin-3-ones, Benzo[a]quinolizin-4-ones, and Benzo[d]azocin-4-ones. Org. Lett. 2006; 8: 5845-5848.
13. Ploypradith P, Petchmanee T, Sahakitpichan P, Litvinas ND, Ruchirawat S. Total Synthesis of Natural and Unnatural Lamellarins with Saturated and Unsaturated D-Rings. J. Org. Chem. 2006; 71: 9440-9448.
14. Kanchanapoom T, Sirikatitham A, Otsuka H, Ruchirawat S. Cuneatoside, a New Megastigmane Diglycoside from Erythroxylum cuneatum Blume. J. Asian Nat. Prod. Res. 2006; 8: 747-751.
15. Boonphong S, Puangsombat P, Baramee A, Mahidol C, Ruchirawat S, Kittakoop P. Bioactive Compounds from Bauhinia purpurea Possessing Antimalarial, Antimycobacterial, Antifungal, Anti-inflammatory, and Cytotoxic Activities. J. Nat. Prod. 2007; 70: 795-801.
16. Ploypradith P, Cheryklin P, Niyomtham N, Bertoni DR, Ruchirawat S. Solid-supported Acids as Mild and Versatile Reagents for the Deprotection of Aromatic Ethers. Org. Lett. 2007; 9: 2637-2640.
17. Yoopan N, Thisoda P, Rangkadilok N, Sahasitiwat S, Pholphana N, Ruchirawat S, Satayavivad J. Cardiovascular Effects of 14-Deoxy-11,12-didehydroandrographolide and Andrographis paniculata Extracts. Planta Med. 2007; 73: 503-511.
18. Kanchanapoom T, Otsuka H, Ruchirawat S. Megastigmane Glucosides from Equisetum debile and E. diffusum. Chem. Pharm. Bull. 2007; 55: 1277-1280.
19. Prachya S, Wiyakrutta S, Sriubolmas N, Ngamrojanavanich N, Mahidol C, Ruchirawat S, Kittakoop P. Cytotoxic Mycoepoxydiene Derivatives from an Endophytic Fungus Phomopsis sp. Isolated from Hydnocarpus anthelminthicus. Planta Med. 2007; in press.
20. Youngsa-ad W, Ngamrojanavanich N, Mahidol C, Ruchirawat S, Prawat H, Kittakoop P. Diterpenoids from the Roots of Croton oblongifolius. Planta Med. 2007; in press.
21. Thasana N, Worayuthakarn R, Kradanrat P, Hohn E, Young L, Ruchirawat S. Copper(I)-mediated and Microwave-assisted Caryl-Ocarboxylic Coupling: Synthesis of Benzopyaranones and Isolamellarin Alkaloids. J. Org. Chem. 2007; accepted.