Dr. Wannaporn Disadee Email:  wan_1976@hotmail.com Office: Laboratory of Medicinal Chemistry (R603) Phone: (66)2 5740622-33 ext. 1609, 1510

1. Development of methodologies for the synthesis of biologically active compounds and design new molecular structures for the study of medicinal chemistry
2. Development of new reagents for the asymmetric synthesis

Publications:

1. Disadee W, Watanabe T, Ishikawa T. Polymer-supported DMI as a Potential Heterogeneous Dehydrating Agent: Application to Esterification and Amidation. Synlett 2003; 115-117.
2. Shikii K, Seki H, Yamaguchi K, Disadee W, Watanabe T, Ishikawa T. Facile Characterization of Polymer-supported Reagents using Cross Polarization Magic Angle Spinning Method in Solid State 13C-NMR. Chem. Pharm. Bull. 2004; 52: 864-865.
3. Disadee W, Ishikawa T. Polymer-supported and Polymeric Chiral Guanidines: Preparation and Application to the Asymmetric Michael Reaction of Iminoacetate with Methyl Vinyl Ketone. Mol. Divers. 2005; 9: 321-331.
4. Disadee W, Ishikawa T. Chirality Transfer from Guanidinium Ylides to 3-Alkenyl (or 3-Alkynyl)aziridine-2-carboxylates and Application to the Syntheses of (2R,3S)-3-Hydroxyleucinate and D-Erythro-sphingosine. J. Org. Chem. 2005; 70: 9399-9406.
5. Disadee W, Ishikawa T, Kawahata M, Yamaguchi K. Guanidinium Ylide Mediated Aziridination: Identification of a Spiro Imidazolidine-oxazolidine Intermediate. J. Org. Chem. 2006; 71: 6600-6603.
6. Manaka T, Nagayama S-I, Disadee W, Yajima N, Kumamoto T, Watanabe T, Ishikawa T, Kawahata M, Yamaguchi K. Ring-opening Reactions of 3-Aryl-1-benzylaziridine-2-carboxylates and Application to the Asymmetric Synthesis of an Amphetamine-type Compound. Helv. Chim. Acta 2007; 90: 128-142.