JULY 2012

Goodman and Gilman's : The pharmacological basis of therapeutics

Laurence L. Brunton

Call no. RM300 G653 2011

Book Description

  • “This 12th edition of the most authoritative book in pharmacology is the best both in content and physical appearance….This edition of Goodman & Gilman's continues to be the most authoritative and widely used resource bridging the discipline of pharmacology with therapeutics. Moreover, readers will find this edition to be substantially improved from past editions in both content and physical appearance.”–Doody's Review Service
  • The most universally respected and read medical text in all of pharmacology, Goodman & Gilman’s The Pharmacological Basis of Therapeutics represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease.
  • Enriched by a new full-color presentation and updated to reflect all critical new developments in drug action and drug-disease interaction, the twelfth edition includes more than 440 color illustrations depicting key principles and actions of specific pathways and therapeutic agents. The companion DVD includes all the images and tables in the text along with narrated animations.
  • Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12e is divided into nine sections, covering:
    • General Principles
    • Neuropharmacology
    • Modulation of Cardiovascular Function
    • Inflammation, Immunomodulation, and Hematopoiesis
    • Endocrine Pharmacology
    • Gastrointestinal Pharmacology
    • Chemotherapy of Infectious Disease
    • Chemotherapy of Neoplastic Diseases
    • Special Systems Pharmacology
  • More than a textbook, Goodman & Gilman's is a working template for the effective and rational prescribing of drugs in daily practice.

The practice of medicinal chemistry

Camille Georges Wermuth

Call no. RS403 P895 2008

Book Description

  • This book collects in one single volume, the practical aspects of Medicinal Chemistry, seen from a chemical point of view, including the wealth of information which chemists accumulate over a career, but generally is never organized and presented in a coherent form in print. Emphasis is given to how medicinal chemists conduct their search for, and design of, new drug entities. In contrast to other books on the market, it focuses on the chemistry, rather than pharmacological concepts or description of the various therapeutic classes of drugs. It should become a standard reference on the tools available to medicinal chemists when designing new drugs.

Key Features

  • These aspects are covered by:
  • Specific chapters devoted to the discovery of new lead compounds, including combinatorial chemistry
  • Clearly written chapters on modern topics such as stereochemical aspects of drug action, the use of X-ray structures of receptors and enzymes in drug discovery, and the contribution of molecular biology to drug discovery
  • Guidelines and operational strategems allowing identification of the portions of the molecule which are important for potency
  • The particular emphasis given to the three-dimensional aspects of the drug-receptor interactions, to the design of peptidomimetic drugs and to the control of the agonist-antagonist transition
  • Chemical solutions to solubility and to formulation problems These sections cover perhaps the most neglected areas in medicinal chemistry books
  • Development of new drugs: legal and economic aspects, constitutes another important area in which chemists are almost wholly self taught following their entry into industry

A pharmacology primer : theory, applications, and methods

Kenakin, Terrence P

Call no. RM301.25 K33P 2009

Book Description

  • Pharmaceutical companies continue to face a growing need for scientists trained in the basics of pharmacology. At GlaxoSmithKline, a pharmaceuticals world-leader, Terry Kenakin regularly teaches this course and has drawn on his valuable experience to write A Pharmacology Primer. This guide has been designed especially for scientists trained in molecular biology and related fields who now need to know the basic theories, principles and practical applications of pharmacology.
  • Important chapters cover: Drug Receptor Theory; Drug Antagonism; The Drug Discovery Process; Pharmacological Assay Formats; Statistics & Experimental Design; and many more!
  • A Pharmacology Primer is stocked with helpful resources – derivations of all formulae in every chapter, a glossary and appendices, scores of full-color illustrations – that further enhance the value and utility of this book.
    • 185 illustrations and figures, four-color throughout
    • Bulleted lists at the end of each section sum up main topics
    • Glossary of Pharmacological Terms included for quick reference

Heterocycles in natural product synthesis

Majumdar , Krishna C.

Call no. QD400.5.S95 H589 2011

Book Description

  • Filling a gap on the market, this handbook and ready reference is unique in its discussion of the usefulness of various heterocyclic systems in the synthesis of natural products.
  • Clearly structured for easy access to the information, each chapter is devoted to a certain class of heterocycle, providing a tabular presentation of the natural products to be covered containing the particular heterocyclic ring system along with their biological profile, occurrence and most important physical properties, backed by the appropriate references. In addition, the application of the heterocyclic system to the synthesis of natural products is covered in detail.
  • Of great interest to organic, natural products, medicinal and biochemists, as well as those working in the pharmaceutical and agrochemical industry.

Steroid chemistry at a glance

Lednicer, Daniel

Call no. QD426 L473S 2011

Book Description

  • The term steroid has become virtually synonymous with drug abuse in sport to the majority of the public. However these steroids - androgens - actually comprise only a single relatively small class of biologically active steroids, and are overshadowed by a large collection of compounds, a sizeable number of which are commercial drugs that share the same structural carbon skeleton. The development of these drugs has led to a large body of organic chemistry often denoted as “Steroid Chemistry”.
  • Steroid Chemistry At A Glance provides a concise overview of the main principles and reactions of steroid chemistry. Topics covered include:
    • history, isolation and structure determination of steroids
    • steroid nomenclature and stereochemistry
    • natural sources of steroids
    • synthesis and reactions of aromatic a-ring steroids, androstanes, and pregnanes
    • steroids with a spirolactone at position 17
    • steroids with hetrocyclic ring A
    • compounds derived from cholesterol
  • Based on the highly successful and student friendly “at a glance” approach, the information is presented in integrated, self contained double page spreads of text and illustrative material. Students of chemistry and pharmacy using Steroid Chemistry at a Glance will find they have a resource with which they can quickly, concisely and confidently acquire, regularly review and revise the basic facts that underpin the properties, synthesis and reactions of this important class of natural products. It will also serve as a handy bench reference for postgraduates and professional chemists.

Immunology at a glance

Playfair, J. H. L.

Call no. QR181 P722I 2009

Book Description

  • Immunology at a Glance is designed to be a concise, readily accessible introduction and revision aid for undergraduate medical and science students. Following the now familiar, easy-to-use format, each topic is presented as a double-page spread with key facts accompanied by clear, informative line diagrams illustrating the essential points.
  • The seventh edition of this popular immunology textbook has been completely updated to ensure that core knowledge about immunology is summarized in the 'at a glance' format.
  • Immunology At A Glance will continue to appeal to all students of biomedical science and medicine who want a quick, yet thorough grasp of immunology.
    • Condenses the subject into 41 double-page spreads, each corresponding roughly to a 50 minute lecture.
    • Presents a schematic diagram on the left page and a concise explanation on the right showing the mechanisms involved in immunological processes.
    • Has been completely updated with particular emphasis on recent understanding of the genetic basis of immune responses Immunology at a Glance will continue to appeal to all students of biomedical science and medicine who want a quick, yet thorough, grasp of immunology.

Molecules and medicine

Corey, E. J.

Call no. RM300 C797M 2007

Book Description

  • This book is appropriate for a broad readership, starting with curious and thoughtful college undergraduates and reaching beyond to professors and researchers in the life sciences, chemistry, and medicine. This book provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine.
  • Molecules and Medicine delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules now in use in modern medicine. Molecule structures and shapes are shown for all of these medicines. The opening sections of the book provide a unique, clear, and concise introduction which enables the reader to understand chemical formulas.