Chutikarn Butkinaree, Ph.D.

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Email: chutikarn@cgi.ac.th

Office: Chulabhorn Graduate Institute Building, 6th floor

Phone: (66)2 554 1900 ext. 2642

Education

Ph.D.

Ph.D. in Biological Chemistry – Biochemistry, Cellular & Molecular Biology Graduate Program

Johns Hopkins University School of Medicine, Maryland, USA

B.A.

B.A. summa cum laude in Biochemistry

Bowdoin College, Maine, USA

Postdoctoral Training

  • Clinical Research Institute of Montreal, Laboratory of Biochemical Neuroendocrinology, Quebec, Canada
  • University Medical Center Göttingen, Department of Cardiology and Pneumology, Göttingen, Germany
  • Johns Hopkins University School of Medicine, Department of Biological Chemistry, Maryland, USA
  • New York University Langone Medical Center, Division of Cardiology Department of Medicine, New York, USA

Research Interests:

  • Molecular mechanisms and regulation of low-density lipoprotein receptor degradation
  • The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in cholesterol homeostasis
  • Apolipoprotein B100 metabolism in dyslipidemia and cardiovascular disease
  • Metabolic signaling pathways and post-translational modifications, such as O-GlcNAcylation and phosphorylation, of proteins responsible for hypercholesterolemia

Selected Publications:

  1. Butkinaree, C., Canuel, M., Essalmani, R., Poirier, S., Benjannet, S., Asselin, M., Roubtsova, A., Hamelin, J., Marcinkiewicz, J., Chamberland, A., Guillemot, J., Mayer, G., Sisodia, S.S., Jacob, Y., Prat, A., and Seidah, N.G. Amyloid precursor-like protein 2 and sortilin do not regulate the PCSK9-mediated low density lipoprotein receptor degradation but interact with each other. J Biol Chem. 290, 18609-18620. (2015)
  2. Butkinaree, C., Guo, L., Ramkhelawon, B., Wanschel, A., Brodsky, J.L., Moore, K.J., and Fisher, E.A. A regulator of secretory vesicle size, Kelch-like protein 12, facilitates the secretion of apolipoprotein B100 and very-low-density lipoproteins. Arterioscler Thromb Vasc Biol. 34, 251-254. (2014)
  3. Butkinaree, C., Park, K., and Hart, G.W. O-Linked β-N-Acetylglucosamine: extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress. Biochim Biophys Acta – General Subjects. 1800, 96-106. (2009)
  4. Butkinaree, C., Cheung, W.D., Park, S., Park, K., Barber, M., and Hart, G.W. Characterization of β-N-acetylglucosaminidase cleavage by caspase-3 during apoptosis. J Biol Chem. 283, 23557-23566. (2008)

Full list of publications