Mayuree Fuangthong, Ph.D.

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Email: mayuree@cri.or.th

Office: Biomedical Science Building, 8th floor, Zone A

Phone: (66)2 553 8558, (66)2 553 8555 ext. 8558, 8365

Research Interests:

My research has been focused on the study of how microorganism responds to stresses, which is a key factor in the infection process. Pathogenic microorganisms encounter various kinds of stresses during their lifetime. One example involves Reactive Oxygen Species, which comprise one of the most deleterious groups of substances to biological systems and are produced by host cells as a defense mechanism against infection by foreign organisms. Additionally, the environment inside host cells, as well as in many natural habitats, is usually limited for one or more essential nutrients. This subjects invading pathogens to nutrient stress. In spite of these barriers, pathogens are able to successfully enter host cells and cause disease. Another area of particular interest is to study the mechanism of drug resistance in human pathogenic bacteria. Knowledge, at a molecular level, of how these microorganisms sense and overcome these stresses will help unravel the complexities of the infection and disease processes in humans.

Selected Publications:

  1. Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa.
    Jaroensuk J, Atichartpongkul S, Chionh YH, Wong YH, Liew CW, McBee ME, Thongdee N, Prestwich EG, DeMott MS, Mongkolsuk S, Dedon PC, Lescar J, Fuangthong M
    Nucleic Acids Resp(2016 Sep 28)
  2. Regulation of Organic Hydroperoxide Stress Response by Two OhrR Homologs in Pseudomonas aeruginosa.
    Atichartpongkul S, Vattanaviboon P, Wisitkamol R, Jaroensuk J, Mongkolsuk S, Fuangthong M
    PLoS One11pe0161982(2016)
  3. IscR plays a role in oxidative stress resistance and pathogenicity of a plant pathogen, Xanthomonas campestris.
    Fuangthong M, Jittawuttipoka T, Wisitkamol R, Romsang A, Duang-nkern J, Vattanaviboon P, Mongkolsuk S
    Microbiol Res170p139-46(2015 Jan)
  4. Derepression of the Bacillus subtilis PerR peroxide stress response leads to iron deficiency.
    Faulkner MJ, Ma Z, Fuangthong M, Helmann JD
    J Bacteriol194p1226-35(2012 Mar)
  5. Exposure of Acinetobacter baylyi ADP1 to the biocide chlorhexidine leads to acquired resistance to the biocide itself and to oxidants.
    Fuangthong M, Julotok M, Chintana W, Kuhn K, Rittiroongrad S, Vattanaviboon P, Mongkolsuk S
    J Antimicrob Chemotherp(2010 Nov 23)
  6. Mutations of ferric uptake regulator (fur) impair iron homeostasis, growth, oxidative stress survival, and virulence of Xanthomonas campestris pv. campestris.
    Jittawuttipoka T, Sallabhan R, Vattanaviboon P, Fuangthong M, Mongkolsuk S
    Arch Microbiol192p331-9(2010 May)
  7. Mini-Tn7 vectors as genetic tools for gene cloning at a single copy number in an industrially important and phytopathogenic bacteria, Xanthomonas spp.
    Jittawuttipoka T, Buranajitpakorn S, Fuangthong M, Schweizer HP, Vattanaviboon P, Mongkolsuk S
    FEMS Microbiol Lett298p111-7(2009 Sep)
  8. The omlA gene is involved in multidrug resistance and its expression is inhibited by coumarins in Xanthomonas campestris pv. phaseoli.
    Fuangthong M, Sallabhan R, Atichartpongkul S, Rangkadilok N, Sriprang R, Satayavivad J, Mongkolsuk S
    Arch Microbiol189p211-8(2008 Mar)
  9. Structural mechanism of organic hydroperoxide induction of the transcription regulator OhrR.
    Newberry KJ, Fuangthong M, Panmanee W, Mongkolsuk S, Brennan RG
    Mol Cell28p652-64(2007 Nov 30)
  10. Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family.
    Hong M, Fuangthong M, Helmann JD, Brennan RG
    Mol Cell20p131-41(2005 Oct 7)
  11. Use of a green fluorescent protein-based reporter fusion for detection of nitric oxide produced by denitrifiers.
    Yin S, Fuangthong M, Laratta WP, Shapleigh JP
    Appl Environ Microbiol69p3938-44(2003 Jul)
  12. The repressor for an organic peroxide-inducible operon is uniquely regulated at multiple levels.
    Mongkolsuk S, Panmanee W, Atichartpongkul S, Vattanaviboon P, Whangsuk W, Fuangthong M, Eiamphungporn W, Sukchawalit R, Utamapongchai S
    Mol Microbiol44p793-802(2002 May)

Full list of publications