Piyarat Govitrapong, Professor


Email: piyarat@cgi.ac.th or piyarat.gov@mahidol.ac.th

Office: Chulabhorn Graduate Institute Building, 4th floor

Phone: (66)2 554 1900 ext. 2415


  • 1992 Postdoctoral: University of Minnesota, USA
  • 1986 Ph.D. (Pharmacology): University of Nebraska, USA
  • 1975 M.S. (Pharmacology), MU
  • 1973 B.S. (Chemistry), MU

Research Interests:

  • Professor Govitrapong is an internationally recognized neuroscientist who has devoted more than 30 years to a multidisciplinary research approach in studying melatonin functions involved in drug addiction, neurodegenerative disorders (Alzheimer’s disease) aging and neural stem cells. She has published more than 170 publications and 19 book chapters. She has received many research awards and honors, including 1st place Outstanding Research Award 2011 from NRCT, Outstanding Scientist Award of the Year 2012 and the recipient of a Distinguished Research Professor from the Thailand Research Fund. She has made several research contributions to neuroscience research and her works have been cited extensively and yielded sustainable benefits to the public.

Selected Publications:

  1. Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway.
    Jenwitheesuk A, Park S, Wongchitrat P, Tocharus J, Mukda S, Shimokawa I, Govitrapong P
    Neurochem Resp(2017 Aug 2)
  2. Neuroprotective effects of melatonin on amphetamine-induced dopaminergic fiber degeneration in the hippocampus of postnatal rats.
    Leeboonngam T, Pramong R, Sae-Ung K, Govitrapong P, Phansuwan-Pujito P
    J Pineal Resp(2017 Nov 17)
  3. Melatonin as a mitochondrial protector in neurodegenerative diseases.
    Wongprayoon P, Govitrapong P
    Cell Mol Life Scip(2017 Aug 8)
  4. Role of Melatonin in Reducing Amphetamine-Induced Degeneration in Substantia Nigra of Rats via Calpain and Calpastatin Interaction.
    Chetsawang J, Mukda S, Srimokra R, Govitrapong P, Chetsawang B
    J Exp Neurosci11p1179069517719237(2017)
  5. The anti-inflammatory effect of melatonin in SH-SY5Y neuroblastoma cells exposed to sublethal dose of hydrogen peroxide.
    Nopparat C, Chantadul V, Permpoonputtana K, Govitrapong P
    Mech Ageing Dev164p49-60(2017 Jun)
  6. High-fat diet-induced plasma protein and liver changes in obese rats can be attenuated by melatonin supplementation.
    Wongchitrat P, Klosen P, Pannengpetch S, Kitidee K, Govitrapong P, Isarankura-Na-Ayudhya C
    Nutr Res42p51-63(2017 Jun)
  7. Activation of melatonin receptor (MT1/2) promotes P-gp transporter in methamphetamine-induced toxicity on primary rat brain microvascular endothelial cells.
    Jumnongprakhon P, Sivasinprasasn S, Govitrapong P, Tocharus C, Tocharus J
    Toxicol In Vitro41p42-48(2017 Jun)
  8. Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway.
    Jenwitheesuk A, Boontem P, Wongchitrat P, Tocharus J, Mukda S, Govitrapong P
    EXCLI J16p340-353(2017)
  9. Neuritogenic activity of bi-functional bis-tryptoline triazole.
    Jiaranaikulwanitch J, Tadtong S, Govitrapong P, Fokin VV, Vajragupta O
    Bioorg Med Chem25p1195-1201(2017 Feb 1)
  10. The Polyherbal Wattana Formula Displays Anti-Amyloidogenic Properties by Increasing α-Secretase Activities.
    Htoo HH, Limsuvan S, Thamsermsang O, Hernandez JF, Checler F, Govitrapong P, Pakaprot N, Akarasereenont P, Vincent B
    PLoS One12pe0170360(2017)
  11. Mechanisms of Melatonin in Alleviating Alzheimer's Disease.
    Shukla M, Govitrapong P, Boontem P, Reiter RJ, Satayavivad J
    Curr Neuropharmacol15p1010-1031(2017)
  12. Melatonin suppresses methamphetamine-triggered endoplasmic reticulum stress in C6 cells glioma cell lines.
    Tungkum W, Jumnongprakhon P, Tocharus C, Govitrapong P, Tocharus J
    J Toxicol Sci42p63-71(2017)
  13. Neuroprotection of agomelatine against cerebral ischemia/reperfusion injury through an antiapoptotic pathway in rat.
    Chumboatong W, Thummayot S, Govitrapong P, Tocharus C, Jittiwat J, Tocharus J
    Neurochem Int102p114-122(2017 Jan)
  14. Effects of melatonin on severe crush spinal cord injury-induced reactive astrocyte and scar formation.
    Krityakiarana W, Sompup K, Jongkamonwiwat N, Mukda S, Pinilla FG, Govitrapong P, Phansuwan-Pujito P
    J Neurosci Res94p1451-1459(2016 Dec)
  15. The Nicotinic α6-Subunit Selective Antagonist bPiDI Reduces Alcohol Self-Administration in Alcohol-Preferring Rats.
    Srisontiyakul J, Kastman HE, Krstew EV, Govitrapong P, Lawrence AJ
    Neurochem Res41p3206-3214(2016 Dec)
  16. Inhibitory effect of melatonin on cerebral endothelial cells dysfunction induced by methamphetamine via NADPH oxidase-2.
    Jumnongprakhon P, Govitrapong P, Tocharus C, Tocharus J
    Brain Res1650p84-92(2016 Nov 1)
  17. Melatonin attenuates the high-fat diet and streptozotocin-induced reduction in rat hippocampal neurogenesis.
    Wongchitrat P, Lansubsakul N, Kamsrijai U, Sae-Ung K, Mukda S, Govitrapong P
    Neurochem Int100p97-109(2016 Nov)
  18. Melatonin Attenuates Methamphetamine-Induced Neurotoxicity.
    Wongprayoon P, Govitrapong P
    Curr Pharm Des22p1022-32(2016)
  19. Association of Neuroprotective Effect of Di-O-Demethylcurcumin on Aβ25-35-Induced Neurotoxicity with Suppression of NF-κB and Activation of Nrf2.
    Pinkaew D, Changtam C, Tocharus C, Govitrapong P, Jumnongprakhon P, Suksamrarn A, Tocharus J
    Neurotox Res29p80-91(2016 Jan)

Full list of publications