CGCB 602 Medicinal Chemistry (3 credits)

Course Description

Various classical and modern synthetic techniques for natural and synthetic drugs will be discussed. Total synthesis as well as semi-synthesis of drugs and drug candidates will be covered. The course will also explore structural modifications of some natural products which lead to compounds with better biological profiles. Concepts of pharmacokinetics, pharmacodynamics and toxicology will also be introduced. In addition, applications of computational chemistry to establish quantitative structure-activity relationship (QSAR) and to investigate the structure of active site of biological targets, as well as to determine ligand-receptor interactions will be explored.

Course Coordinator: Poonsakdi Ploypradith, Ph.D.