Montakarn Chittchang, Ph.D.

montakarn.jpg

Affiliation: Laboratory of Medicinal Chemistry (R403C; Ext. 8965)
Office: R413 (Ext. 8964)
E-mail: montakarn@cri.or.th

Education

1996B.Sc. (Pharmacy), 1st Class HonorsChulalongkorn University, Thailand
2004Ph.D. (Pharmaceutical Sciences)University of Missouri-Kansas City, USA

Research Interests

Previous projects involved the challenging area of peptide and protein delivery by modifying the secondary structure of polypeptides to enhance their paracellular transport.

Current research interests focus on the investigations of biologically-active compounds, especially those with anticancer activities. The scope of ongoing research encompasses mechanism-based biological screenings, structure-activity relationship (SAR) studies, as well as drug development and delivery.

Selected Publications

  1. Theppawong A, Ploypradith P, Chuawong P, Ruchirawat S, Chittchang M. Facile and Divergent Synthesis of Lamellarins and Lactam-Containing Derivatives with Improved Drug Likeness and Biological Activities. Chem. Asian J. 2015; 10: 2631-2650. Abstract
  2. Tangdenpaisal K, Worayuthakarn R, Karnkla S, Ploypradith P, Intachote P, Sengsai S, Saimanee B, Ruchirawat S, Chittchang M. Designing New Analogs for Streamlining the Structure of Cytotoxic Lamellarin Natural Products. Chem. Asian J. 2015; 10: 925-937. Abstract
  3. Thipnate P, Chittchang M, Thasana N, Saparpakorn P, Ploypradith P, Hannongbua S. Exploring the Molecular Basis for Selective Cytotoxicity of Lamellarins against Human Hormone-dependent T47D and Hormone-independent MDA-MB-231 Breast Cancer Cells. Monatsh. Chem. 2011; 142: 97-109. Abstract
  4. Chittchang M, Gleeson MP, Ploypradith P, Ruchirawat S. Assessing the Drug-likeness of Lamellarins, a Marine-derived Natural Product Class with Diverse Oncological Activities. Eur. J. Med. Chem. 2010; 45: 2165-2172. Abstract
  5. Chittchang M, Batsomboon P, Ruchirawat S, Ploypradith P. Cytotoxicities and Structure-activity Relationships of Natural and Unnatural Lamellarins toward Cancer Cell Lines. ChemMedChem 2009; 4: 457-465. Abstract
  6. Chittchang M, Mitra AK, Johnston TP. Interplay of Secondary Structure and Charge on the Diffusion of a Polypeptide through Negatively-charged Aqueous Pores. Pharm. Res. 2007; 24: 502-511. Abstract
  7. Salamat-Miller N, Chittchang M, Johnston, TP. The Use of Mucoadhesive Polymers in Buccal Drug Delivery. Adv. Drug Deliv. Rev. 2005; 57: 1666-1691. Abstract
  8. Salamat-Miller N, Chittchang M, Mitra AK, Johnston TP. A Randomly Coiled, High-molecular-weight Polypeptide Exhibits Increased Paracellular Diffusion In Vitro and In Situ Relative to the Highly Ordered Alpha-helix Conformer. Pharm. Res. 2005; 22: 245-254. Abstract
  9. Johnston TP, Kuchimanchi KR, Alur HH, Chittchang M, Mitra AK. Inducing a Change in the Pharmacokinetics and Biodistribution of Poly-L-lysine in Rats by Complexation with Heparin. J. Pharm. Pharmacol. 2003; 55: 1083-1090. Abstract
  10. Salamat-Miller N, Chittchang M, Mitra AK, Johnston TP. Shape Imposed by Secondary Structure of a Polypeptide Affects Its Free Diffusion through Liquid-filled Pores. Int. J. Pharm. 2002; 244: 1-8. Abstract
  11. Chittchang M, Salamat-Miller N, Alur HH, Vander Velde DG, Mitra AK, Johnston TP. Poly(L-lysine) as a Model Drug Macromolecule with Which to Investigate Secondary Structure and Membrane Transport, Part II: Diffusion Studies. J. Pharm. Pharmacol. 2002; 54: 1497-1505. Abstract
  12. Chittchang M, Alur HH, Mitra AK, Johnston TP. Poly(L-lysine) as a Model Drug Macromolecule with Which to Investigate Secondary Structure and Membrane Transport, Part I: Physicochemical and Stability Studies. J. Pharm. Pharmacol. 2002; 54: 315-323. Abstract

Students Supervised

Thesis Advisees:

2012_nattapong.jpg Mr. Atiruj Theppawong
M.Sc. (Chemical Biology), Chulabhorn Graduate Institute, Thailand, 2014
B.Sc. (Biochemistry & Biochemical Technology), Chiang Mai University, Thailand, 2011


2010_kamil.jpg Ms. Kamil Prajapati
M.Sc. (Chemical Biology), Chulabhorn Graduate Institute, Thailand, 2012
M.Sc. (Environment and Public Health Microbiology), Tribhuwan University, Nepal, 2007
B.Sc. (Microbiology), Tribhuwan University, Nepal, 2004

Co-advisees:

2009_parichart.jpg Ms. Parichart Kedkum
M.Sc. (Chemical Biology), Chulabhorn Graduate Institute, Thailand, 2012
B.Sc. (Chemistry), Chulalongkorn University, Thailand, 2009


2008_jarinee.jpg Ms. Jarinee Maneekul
M.Sc. (Chemical Biology), Chulabhorn Graduate Institute, Thailand, 2010
B.Sc. (Pharmacy), Chiang Mai University, Thailand, 2008