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Prasat Kittakoop, Ph.D.

Affiliation: Laboratory of Natural Products (R503 & R304B; Ext. 1514-5 & 1316)
Office: R513 (Ext. 1519)
E-mail: prasat@cri.or.th

Education

1989	B.Sc. (Chemistry), Honors	Chiang Mai University, Thailand
1992	Ph.D. (Biochemistry)	University of Wales, UK

Dr. Prasat Kittakoop has focused on the isolation and characterization of bioactive natural products from plants, fungi, and marine invertebrates. Currently, he is interested in the application of nanoparticles in biological systems. In addition, asymmetric synthesis via Aldol or nitro condensation by enzymatic catalysis or by homogeneous catalysts is also of his interest.

Selected Publications

Molee, W.; Phanumartwiwath, A.; Kesornpun, C.; Sureram, S.; Ngamrojanavanich, N.; Ingkaninan, K.; Mahidol, C.; Ruchirawat, S.; Kittakoop P. Naphthalene derivatives and quinones from Ventilago denticulata and their nitric oxide radical scavenging, antioxidant, cytotoxic, antibacterial, and phosphodiesterase inhibitory activities. Chem. Biodivers. 2018 Jan 11. doi: 10.1002/cbdv.201700537; in press.
Chawengrum, P.; Boonsombat, J.; Kittakoop, P.; Mahidol, C.; Ruchirawat, S.; Thongnest, S. Cytotoxic and antimicrobial labdane and clerodane diterpenoids from Kaempferia elegans and Kaempferia pulchra, Phytochem. Lett. 2018, 24, 140-144.
Bag, B.G.; Barai, A.C.; Wijesekera, K.; Kittakoop, P. First vesicular self-assembly of crotocembraneic acid, a nano-sized fourteen membered macrocyclic diterpenic acid, ChemistrySelect 2017, 2, 4969-4973.
Wijesekera, K.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Metabolite diversification by cultivation of the endophytic fungus Dothideomycete sp. in halogen containing media: Cultivation of terrestrial fungus in seawater, Bioorg. Med. Chem. 2017, 25, 2868-2877.
Chottanapund, S.; Van Duursen, M.B.M.; Zwartsen, A.; Timtavorn, S.; Navasumrit, P.; Kittakoop, P.; Sureram, S.; Ruchirawat, M.; Van den Berg, M. Depsidones inhibit aromatase activity and tumor cell proliferation in a co-culture of human primary breast adipose fibroblasts and T47D breast tumor cells, Toxicology Reports 2017, 4, 165-171.
Kesornpun, C.; Aree, T.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Water-assisted nitrile oxide cycloadditions: synthesis of isoxazoles and stereoselective syntheses of isoxazolines and 1,2,4-oxadiazoles, Angew. Chem. Int. Ed. 2016, 55, 3997-4001.
Wibowo, M.; Prachyawarakorn, V.; Aree, T.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Cytotoxic sesquiterpenes from the endophytic fungus Pseudolagarobasidium acaciicola, Phytochemistry 2016, 122, 126-138.
Darsih, C.; Prachyawarakorn, V.; Wiyakrutta, S.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Cytotoxic metabolites from the endophytic fungus Penicillium chermesinum : Discovery of a cysteine-targeted michael acceptor as a pharmacophore for fragment-based drug discovery, bioconjugation and click reactions, RSC Adv. 2015, 5, 70595-70603.
Ngokpol, S.; Suwakulsiri, W.; Sureram, S.; Lirdprapamongkol, K.; Aree, T.; Wiyakrutta, S.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Drimane sesquiterpene-conjugated amino acids from a marine isolate of the fungus Talaromyces minioluteus (Penicillium Minioluteum), Mar. Drugs 2015, 13, 3567-3580.
Ganihigama, D. U.; Sureram, S.; Sangher, S.; Hongmanee, P.; Aree, T.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Antimycobacterial activity of natural products and synthetic agents: pyrrolodiquinolines and vermelhotin as anti-tubercular leads against clinical multidrug resistant isolates of Mycobacterium tuberculosis, Eur. J. Med. Chem. 2015, 89, 1-12.
Hewage, R.T.; Aree, T.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. One strain-many compounds (OSMAC) method for production of polyketides, azaphilones, and an isochromanone using the endophytic fungus Dothideomycete sp., Phytochemistry 2014, 108, 87-94.
Mahidol, C.; Kittakoop, P.; Prachyawarakorn, V.; Pailee, P.; Prawat, H.; Ruchirawat, S. Recent investigations of bioactive natural products from endophytic, marine-derived, insect pathogenic fungi and Thai medicinal plants, Pure Appl. Chem. 2014, 86, 979-993.
Wibowo, M.; Prachyawarakorn, V.; Aree, T.; Wiyakrutta, S.; Mahidol, C.; Ruchirawat; S.; Kittakoop, P. Tricyclic and spirobicyclic norsesquiterpenes from the endophytic fungus Pseudolagarobasidium acaciicola, Eur. J. Org. Chem. 2014, 19, 3976–3980.
Dendup, T.; Prachyawarakorn, V.; Pansanit, A.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. α-Glucosidase inhibitory activities of isoflavanones, isoflavones, and pterocarpans from Mucuna pruriens, Planta Medica 2014, 80, 604-608.
Sangsuwan, R.; Sangher, S.; Aree, T.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. An organocatalyst from renewable materials for the synthesis of coumarins and chromenes: three-component reaction and multigram scale synthesis, RSC Adv. 2014, 4, 13708-13718.
Kittakoop, P.; Mahidol, C.; Ruchirawat, S. Alkaloids as important scaffolds in therapeutic drugs for the treatments of cancer, tuberculosis, and smoking cessation, Curr. Top. Med. Chem. 2014, 14, 239-252.
Pansanit, A.; Park, E. J.; Kondratyuk, T. P.; Pezzuto, J. M.; Lirdprapamongkol, K.; Kittakoop, P. Vermelhotin, an anti-inflammatory agent, suppresses nitric oxide production in RAW 264.7 cells via p38 inhibition, J. Nat. Prod. 2013, 76, 1824-1827.
Prachyawarakorn, V.; Sangpetsiripan, S.; Surawatanawong, P.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Flavans from Desmos cochinchinensis as potent aromatase inhibitors, Med. Chem. Commun. 2013, 4, 1590-1596.
Sureram, S.; Kesornpun, C.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Directed biosynthesis through biohalogenation of secondary metabolites of the marine-derived fungus Aspergillus unguis, RSC Adv. 2013, 3, 1781-1788.
Phakeovilay, C.; Disadee, W.; Sahakitpichan, P.; Sitthimonchai, S.; Kittakoop, P.; Ruchirawat, S.; Kanchanapoom, T. Phenylethanoid and flavone glycosides from Ruellia tuberosa L., J. Nat. Med. 2013, 67, 228-233.
Boonman, N.; Prachya, S.; Boonmee, A.; Kittakoop, P.; Wiyakrutta, S.; Sriubolmas, N.; Warit, S.; Chusattayanond, A. D. In vitro acanthamoebicidal activity of fusaric acid and dehydrofusaric acid from an endophytic fungus Fusarium sp. Tlau3, Planta Medica 2012, 78, 1562-1567.
Senadeera, S. P. D.; Wiyakrutta, S.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. A novel tricyclic polyketide and its biosynthetic precursor azaphilone derivatives from the endophytic fungus Dothideomycete sp., Org. Biomol. Chem. 2012, 10, 7220-7226.
Sureram, S.; Senadeera, P. D. S.; Hongmanee, P.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis, Bioorg. Med. Chem. Lett. 2012, 22, 2902-2905.
Pansanit, A.; Ingavat, N.; Aree, T.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Nitrone formation in phosphate buffer and aqueous solutions: novel chemistry inspired by a natural product, Tetrahedron Lett. 2012, 53, 2129–2131.
Sureram, S.; Wiyakrutta, S.; Ngamrojanavanich, N.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Depsidones, aromatase inhibitors and radical scavenging agents from the marine-derived fungus Aspergillus unguis CRI282-03, Planta Medica 2012, 78, 582-588.
Pripdeevech, P.; Pitija, K.; Rujjanawate, C.; Pojanagaroon, S.; Kittakoop, P.; Wongpornchai, S. Adaptogenic-active components from Kaempferia parviflora rhizomes, Food Chemistry 2012, 132, 1150–1155.
Pailee, P.; Prachyawarakorn, V.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Protoberberine alkaloids and cancer chemopreventive properties of compounds from Alangium salviifolium, Eur. J. Org. Chem. 2011, 3809–3814.
Ingavat, N.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Asperaculin A, a sesquiterpenoid from a marine-derived fungus, Aspergillus aculeatus, J. Nat. Prod. 2011, 74, 1650-1652.
Bajgai, S. P.; Prachyawarakorn, V.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Hybrid flavan-chalcones, aromatase and lipoxygenase inhibitors from Desmos cochinchinensis, Phytochemistry 2011, 72, 2062-2067.
Antia, B. S.; Aree, T.; Kasettrathat, C.; Wiyakrutta, S.; Ekpa, O. D.; Ekpe, U. J.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Itaconic acid derivatives and diketopiperazine from the marine-derived fungus Aspergillus aculeatus CRI322-03, Phytochemistry 2011, 72, 816-820.
Tianpanich, K.; Prachya, S.; Wiyakrutta, S.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Radical scavenging and antioxidant activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp., J. Nat. Prod. 2011, 74, 79-81.
Charoenchai, P.; Vajrodaya, S.; Somprasong, W.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Part 1: antiplasmodial, cytotoxic, radical scavenging and antioxidant activities of Thai plants in the family Acanthaceae, Planta Medica 2010, 76, 1940-1943.
Aree, T.; Antia, B. S.; Ekpa, O. D.; Kittakoop, P. Paraherquamide E, Acta Cryst. 2010, E66, o2227.
Chomcheon, P.; Wiyakrutta, S.; Aree, T.; Sriubolmas, N.; Ngamrojanavanich, N.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Curvularides A-E, antifungal hybrid peptide-polyketides from the endophytic fungus Curvularia geniculata, Chem. Eur. J. 2010, 16, 11178-11185.
Parks, J.; Gyeltshen, T.; Prachyawarakorn, V.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Glutarimide alkaloids and a terpenoid benzoquinone from Cordia globifera, J. Nat. Prod. 2010, 73, 992-994.
Antia, B. S.; Pansanit, A.; Ekpa, O. D.; Ekpe, U. J.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. ∝-Glucosidase, aromatase inhibitory and antiplasmodial activities of a biflavonoid GB1 from Garcinia kola stem bark, Planta Medica 2010, 76, 276-277.
Sae-Tang, D.; Kittakoop, P.; Hannongbua, S. Roles of key residues specific to cyclooxygenase II: an ONIOM study, Monatsh. Chem. 2009, 140, 1533-1541.
Ingavat, N.; Dobereiner, J.; Wiyakrutta, S.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Aspergillusol A, an ∝-glucosidase inhibitor from a marine-derived fungus Aspergillus aculeatus, J. Nat. Prod. 2009, 72, 2049-2052.
Chirasuwan, N.; Chaiklahan, R.; Kittakoop, P.; Chanasattru, W.; Ruengjitchatchawalya, M.; Tanticharoen, M.; Bunnag, B. Anti HSV-1 activity of sulphoquinovosyl diacylglycerol isolated from Spirulina platensis, ScienceAsia 2009, 35, 137-141.
Atjanasuppat, K.; Wongkham, W.; Meepowpan, P.; Kittakoop, P.; Sobhon, P.; Bartlett, A.; Whitfield, P. J., In vitro screening for anthelmintic and antitumour activity of ethnomedicinal plants from Thailand, J. Ethnopharmacol. 2009, 123, 475-82.
Dettrakul, S.; Surerum, S.; Rajviroongit, S.; Kittakoop, P. Biomimetic transformation and biological activities of globiferin, a terpenoid benzoquinone from Cordia globifera, J. Nat. Prod. 2009, 72, 861–865.
Chomcheon, P.; Wiyakrutta, S.; Sriubolmas, N.; Ngamrojanavanich, N.; Kengtong, S.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Aromatase inhibitory, radical scavenging, and antioxidant activities of depsidones and diaryl ethers from the endophytic fungus Corynespora cassiicola L36, Phytochemistry 2009, 70, 407–413.
Chomcheon, P.; Wiyakrutta, S.; Sriubolmas, N.; Ngamrojanavanich, N.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Metabolites from the endophytic mitosporic Dothideomycete sp. LRUB20, Phytochemistry 2009, 70, 121–127.
Kasettrathat, C.; Ngamrojanavanich, N.; Wiyakrutta, S.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Cytotoxic and antiplasmodial substances from marine-derived fungi, Nodulisporium sp. and CRI247-01, Phytochemistry 2008, 69, 2621–2626.
Prachyawarakorn, V.; Mahidol, C.; Sureram, S.; Sangpetsiripan, S.; Wiyakrutta, S.; Ruchirawat, S.; Kittakoop P. Diketopiperazines and phthalides from a marine derived fungus of the order Pleosporales, Planta Medica 2008, 74, 69–72.
Youngsa-ad, W.; Ngamrojanavanich, N.; Mahidol, C.; Ruchirawat, S.; Prawat, H.; Kittakoop, P. Diterpenoids from the roots of Croton oblongifolius, Planta Medica 2007, 73, 1491-1494.
Prachya, S.; Wiyakrutta, S.; Sriubolmas, N.; Ngamrojanavanich, N.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Cytotoxic mycoepoxydiene derivatives from an endophytic fungus Phomopsis sp. isolated from Hydnocarpus anthelminthicus, Planta Medica 2007, 73, 1418-1420.
Boonphong, S.; Puangsombat, P.; Baramee, A.; Mahidol, C.; Ruchirawat, S.; Kittakoop P. Bioactive compounds from Bauhinia purpurea possessing antimalarial, antimycobacterial, antifungal, antiinflammatory, and cytotoxic activities. J. Nat. Prod. 2007, 70, 795-801.