Nopporn Thasana, Ph.D.

Research Scientist II
Laboratory of Medicinal Chemistry
Chulabhorn Research
Lecturer
Chemical Biology Program
Chulabhorn Graduate Institute
Mobile +6684 643 2728
Telephone +66 2 553 8555 ext. 8962
Fax +66 2 553 8572
E-mail nopporn@cri.or.th

Education

1993B.Sc. (Chemistry), 2nd Class HonorsRamkhamhaeng University, Thailand
1996M.Sc. (Organic Chemistry)Mahidol University, Thailand
2003Ph.D. (Organic Chemistry)Mahidol University, Thailand

Research Interests

Green chemistry, Microwave-assisted organic synthesis and organometallic chemistry
Research in Dr. Thasana’s lab focuses on the synthesis of bioactive lactone and lactam molecules. His group studies the Cu(I)-mediated/MW-assisted C-O/N bond formation under “subcritical water” conditions as “Green Chemistry” to synthesize bioactive benzopyranone (urolithins A-C), novobiocin, and indolo-2-carboxamide analogs. Moreover chemistry of oxazolone and coumarin derivatives has been studied to develop efficient synthetic routes for a wide range of structurally complex natural products using metal catalysis or metal-free condition in key step. The natural bioactive alkaloids, lamellarin, clausenamide and naucleamide derivatives, will be synthesized using the developed synthetic methodology.

Natural products chemistry
A part from his interest in organic synthesis, he is also interested the screening and isolation of Lycopodium alkaloids having complex skeleton characteristics from Lycopodaceae/Huperziaceae plants. Huperzine A (HupA), firstly isolated from Huperzia serrata a traditional Chinese folk medicine, is a well known biological activity for acetylcholinesterase (AChE) inhibition. The investigation of phytochemical constituents of club mosses in Thailand has been studied. As well as dimer and hybrid of huperzine A have been synthesized to develop a more potent AChE inhibitor.

Publications

Students Supervised

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Ms. Sasiwadee Boonya-udtayan
ID:07110206
Ph.D. student (2007-2011)
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Mr. Prattya Nealmongkol
ID:08110208
Ph.D. student (2008-2013)
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Mr. Thanasan Nilsu
ID:12040102
Ph.D. student (2012-2018)
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Ms. Pornkanok Pongpamorn
ID:13020201/15050202
Ph.D. student (2013-2018)
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Mr. Prateep Worawittayanon
ID:09110204
M.Sc. student (2010-2013)
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Ms. Apiwan Jumraksa
ID:12020205
M.Sc. student (2012-2015)
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Ms. Chiranan Pramthiasong
ID:14020208
M.Sc. student (2014-2016)
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Ms. Wareepat Tiyabhorn
ID:16020203
M.Sc. student (2016-2018)
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Ms. Sirikan Deesiri
ID:16020208
M.Sc. student (2016-2018)

Research Assistant

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Dr. Rattana Worayuthakarn
(2007-present)
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Ms. Sokornrat Thoroad
(2010-2014)
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Ms. Vannapha Pharikronburee
(2012-2014)
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Mr. Wachirasak Thaisang
(2013-present)
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Ms. Sakuna Wan-erlor
(2014-2016)
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Ms. Wanlaya Thamnarak
(2014-present)
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Ms. Salisa Pimmason
(2014-2016)
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Mr. Kanyanut Boontan
(2017-present)
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Mr. Arantham Pirombua
(2017-present)

Group Activities

Group trip

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Khangkrachan Petchburi (2010)
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Fog Sea @ PaNoenThung Petchburi (2010)

NT group photos

2012
2012
2014
2014
2016
2016

2016 (with 2 training students in summer 2016)

2016

2017 (with 3 training students in summer 2017)

2017

2018

2018 2018 2018

2018 (with 4 training students in summer 2018)

2018