August 2012

The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery

An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery highlights current analytical approaches, industry practices, and modern strategies for the characterization of both peptides and proteins in drug discovery.

Illustrating the critical role MS technology plays in characterizing target proteins and protein products, the methods used, ion mobility, and the use of microwave radiation to speed proteolysis, the book also covers important emerging applications for neuroproteomics and antigenic peptides. Placing an emphasis on the pharmaceutical industry, the book stresses practice and applications, presenting real-world examples covering the most recent advances in mass spectrometry, and providing an invaluable resource for pharmaceutical scientists in industry and academia, analytical and bioanalytical chemists, and researchers in protein science

Heterocyclic compounds play a vital role in the metabolism of living cells. Their practical applications range from extensive clinical use to fields as diverse as agriculture, photography, biocide formulation and polymer science.

Written by leading scholars and industry experts, the Handbook of Heterocyclic Chemistry is thoroughly updated with over 50% new content. It has been rewritten with a new expanded author team, who have carefully distilled essential information on the reactivity, structure and synthesis of heterocycles from the 2008 major reference work Comprehensive Heterocyclic Chemistry III.

To bring the work up to date the author team have also added new synthetic examples and structures, key applications and new references from 2008-2010.

Contains more than 1500 clearly drawn structures and reactions. The highly systematic coverage given to the subject makes this one of the most authoritative single-volume accounts of modern heterocyclic chemistry available and should be useful reference for those teaching a heterocyclic course.

Pollutants, Human Health and the Environment is a comprehensive, up-to-date overview of environmental pollutants that are of current concern to human health.

Clearly structured throughout, the main body of the book is divided by pollutant type with a chapter devoted to each group of pollutants. Each chapter follows a similar format to facilitate comparison and discussion. For each pollutant, the authors describe the sources, pathways, environmental fate and sinks as well as known toxicological effects.

Importantly, the second chapter on heavy metals and other inorganic substances deals with trace element deficiencies which can have serious problems for human health. Some rocks and soils are naturally low in some trace elements and intensive agriculture over the past half century has effectively mined many trace elements reducing their levels in soils and crops. The final chapter is a discussion about the various risk assessment frameworks and regulations covering the main pollutants.

Learn how to think and engage like a scientist! BIOLOGY: THE DYNAMIC SCIENCE, Second Edition, provides you with a deep understanding of the core concepts in Biology, building a strong foundation for additional study. In a fresh presentation, the authors explain complex ideas clearly and describe how biologists collect and interpret evidence to test hypotheses about the living world. Russell, Hertz, and McMillan will spark your curiosity about living systems instead of burying it under a mountain of disconnected facts. You will learn what scientists know about the living world, how they know it, and what they still need to learn. The accompanying Aplia for Biology interactively guides you through the thought processes and procedures that scientists use in their research and helps you apply and synthesize content from the text. Overall, you will learn how to think like a scientist and engage in the scientific process yourself.

This exhaustive listing of almost all marine natural products known to date adopts a unique approach in its classification of the compounds by biological species. It also provides background information on the respective species, based on the biological classification of the organisms from which these compounds are derived. The treatise covers more than 8,700 formula, 14,000 references, and 650 websites on almost 1700 pages.

From the contents:General and Bibliographic Resources, Archaea (Archaebacteria) and Eubacteria, Photosynthetic Eucaryotes, Fungi and other non-photosynthetic unicellular eucaryotes, Diploblastic animals, Protostomes, Deuterostomes

Indispensable for marine biologists and chemists exploring natural products, as well as for the pharmaceutical and food industries and the agribusiness.